NEW 1,4-DISUSTITUTED-6-HYDROXYPERHYDRO-1,4-DIAZEPINE2,3-DIONE DERIVATIVES

New Substituted C(14)-andrographolide Derivatives with Potent Cytotoxic Activities

Andrographolde is the major secondary metabolite from the plant Andrographis paniculata. It has been found to show cytotoxic activity. To improve the efficacy on cytotoxic activity, a series of new sulfonyl derivatives have been synthesized by structural modifications of the andrographolide at C-2 position. All the derivatives were tested for their cytotoxic activity against human small lung ca...

Cover vol. 14, no. 6, December 2017

Lit Lunch 2/6/14

The putative eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved and essential protein present in all organisms except bacteria. To be activated, eIF5A requires the conversion of a specific residue of lysine into hypusine. This hypusine modification occurs posttranslationally in two enzymatic steps, and the polyamine spermidine is the substrate. Despite having an essential...

Lecture 6 — April 14 , 2017

A zero sum game is a simultaneous move game between 2 players. Such a game is represented by a matrix A ∈ Rm×n. The strategies of the “row” (resp. “column”) player are the rows (resp. columns) of A. If the row player plays strategy i ∈ [m] and the column player plays j ∈ [n] then the outcome is Aij . 1 Interpret this as that the row player pays Aij amount of money to the column player, therefor...

Qbox400 Brochure 6-14-11